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Long-time Senate Judiciary Committee member Arlen Specter lost his bid for a sixth term Tuesday night, after switching to the Democratic party last year in an attempt to salvage his political career.

Specter, 80, lost the Democratic Senate primary in Pennsylvania to Rep. Joe Sestak. His defeat is part of a wave of anti-incumbent anger that’s sweeping out veterans of both parties. Specter abandoned the GOP after polls showed him badly trailing ex-Rep. Pat Toomey for the Republican nomination. Read the New York Times story here. Paul Kane in the Washington Post lists some of Specter’s most memorable career highlights here.